Characterization of Best Optimized Levobunolol Hydrochloride Occusert Formulations with Special Reference to Glaucoma Treatment
نویسندگان
چکیده
treatment, biologically. Levobunolol HCl occuserts were prepared using hydroxypropyl methylcellulose (HPMC, 3% & 4%), poly vinyl pyrrolidone (PVP, 1%), methyl cellulose (MC, 1% & 2%) as polymers by solvent casting technique with objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy. Based on their physiochemical and invitro drug release characterization, formulations (F & F )containing 4 % and 3 % HPMC were selected as best optimized formulations. Further, 2 1
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